Anti-inflammatory and analgesic effects of cannabidiolic acid as a proposal for use in dentistry: a systematic review.

Authors

  • Brenda Winona Santos Universidade Federal do Paraná
  • Idonilton da Conceição Fernandes Federal University of Parana
  • Bruna dos Santos Ferreira Federal University of Parana
  • Yasmin Dallarmi Miguel ILAPEO FACULTY
  • Josiane de Fatima Gaspari Dias Federal University of Parana
  • Luciane Dalarmi Federal University of Parana
  • Deise Prehs Montrucchio Federal University of Parana
  • Marillis Dallarmi Miguel Federal University of Parana

DOI:

https://doi.org/10.54397/rcfaminas.v20i1.957

Keywords:

Cannabinoids, Dentistry, Inflammation

Abstract

Introduction: Cannabidiolic acid (CBDA), a compound derived from Cannabis sativa, exhibits promising anti-inflammatory and analgesic properties. Its use in dentistry is proposed as an alternative to conventional anti-inflammatory agents due to its selective modulation of the inflammatory response. Objective: This article systematically reviews the anti-inflammatory and analgesic effects of CBDA and proposes its application in dentistry, particularly for the management of pain and inflammation during invasive procedures. Methodology: The systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and the recommendations of Cochrane Collaboration (PROSPERO: CRD CRD42024588684), including searches in the PubMed, Web of Science, and Embase databases. Clinical trials, in vitro, and in vivo studies investigating the anti-inflammatory and adverse effects of CBDA were analyzed. Results and Discussion: Eight studies were included, highlighting CBDA as a selective inhibitor of the COX-2 enzyme and a reducer of inflammatory biomarkers, such as prostaglandin E2. In preclinical models, CBDA demonstrated anti-hyperalgesic effects and a reduction in inflammatory stress, suggesting its potential for pain and inflammation management in dentistry. Its superior safety profile indicates a promising option for patients with contraindications to traditional anti-inflammatory drugs. Conclusion: CBDA presents itself as an effective and safe alternative for pain and inflammation management in dental contexts, particularly in cases of acute pain and postoperative inflammation. Further clinical studies are necessary to confirm its efficacy and safety in humans, but the initial results are encouraging for its use in dental practice.

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References

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Published

2025-11-17

How to Cite

Santos, B. W., Fernandes, I. da C., Ferreira, B. dos S., Miguel, Y. D., de Fatima Gaspari Dias, J., Dalarmi , L., … Miguel, M. D. (2025). Anti-inflammatory and analgesic effects of cannabidiolic acid as a proposal for use in dentistry: a systematic review. REVISTA CIENTÍFICA DA FAMINAS, 20(1), 121–132. https://doi.org/10.54397/rcfaminas.v20i1.957

Issue

Vol. 20 No. 1 (2025): REVISTA CIENTÍFICA DA FAMINAS

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Revisão

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Copyright (c) 2025 Brenda Winona santos, Idonilton da Conceição Fernandes, Bruna dos Santos Ferreira, Yasmin Dallarmi Miguel, Josiane de Fatima Gaspari Dias, Luciane Dalarmi, Deise Prehs Montrucchio, Marilis Dallarmi Miguel

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