The role of macronutrients in the muscle hypertrophy response during resistance training: a narrative review.

Authors

  • Marcos Vinícius Nogueira dos Santos Faculdade de Minas FAMINAS-BH
  • Adolfo César da Silva Pires Faculdade de Minas FAMINAS-BH
  • Ana Luísa Heringer Duarte Faculdade de Minas FAMINAS-BH
  • Marcio Leandro Ribeiro de Souza Faculdade de Minas Faminas-BH https://orcid.org/0000-0003-1517-4516

Keywords:

Macronutrients, Muscle hypertrophy, Protein, Resistance training, Sports nutrition

Abstract

Resistance training is widely recognized for its effectiveness in promoting muscle hypertrophy, strength, and improving physical fitness. However, for these adaptations to occur optimally, nutrition plays a fundamental role, especially regarding the adequate and strategic intake of macronutrients: proteins, carbohydrates, and lipids. This narrative review aims to verify the role of each macronutrient in the hypertrophy process, with an emphasis on nutritional timing and individual needs. Protein, particularly that of high quality, is essential for muscle protein synthesis, and a consumption of between 1.6 and 2.2 g/kg/day is recommended, with adjustments for specific populations, such as the elderly. Carbohydrates contribute to the maintenance of glycogen stores and act in the modulation of fatigue and muscle recovery. Lipids, although less discussed, have important functions in hormonal regulation and as an energy substrate in low- to moderate-intensity training. The interaction between diet and training shows that a strategically planned diet enhances the effects of exercise, making nutritional intake a central element in optimizing hypertrophy. It is concluded that the conscious and personalized manipulation of macronutrients, combined with the regular practice of resistance training, represents an effective approach to maximize the results of strength, muscle mass and physical performance.

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Author Biographies

Marcos Vinícius Nogueira dos Santos, Faculdade de Minas FAMINAS-BH

Graduando em Nutrição na Faculdade de Minas Faminas-BH

Adolfo César da Silva Pires, Faculdade de Minas FAMINAS-BH

Graduando em Nutrição na Faculdade de Minas Faminas-BH

Ana Luísa Heringer Duarte, Faculdade de Minas FAMINAS-BH

Graduanda em Nutrição na Faculdade de Minas Faminas-BH

Marcio Leandro Ribeiro de Souza, Faculdade de Minas Faminas-BH

Doutor e Mestre pela Faculdade de Medicina da UFMG. Possui quatro pós-graduações Lato sensu em Nutrição Clínica Funcional, Nutrição Esportiva Funcional, Fitoterapia Funcional e Treinamento Desportivo. É professor no curso de Nutrição na Faculdade de Minas FAMINAS-BH. É professor nos cursos de pós-graduação da VP Centro de Nutrição Funcional. É autor dos livros: "Nutrientes aplicados à prática clínica" e "Suplementação Nutricional: guia prático para o atendimento".

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Published

2025-12-08

How to Cite

Santos, M. V. N. dos, Pires, A. C. da S., Duarte, A. L. H., & Souza, M. L. R. de. (2025). The role of macronutrients in the muscle hypertrophy response during resistance training: a narrative review. REVISTA CIENTÍFICA DA FAMINAS, 20(2), 90–111. Retrieved from https://periodicos.faminas.edu.br/index.php/RCFaminas/article/view/998