Influência da suplementação da melatonina e triptofano na qualidade do sono de mulheres em tratamento do câncer de mama: uma revisão integrativa
Keywords:
melatonina, triptofano, sono, câncer de mamaAbstract
Melatonin is a useful therapeutic agent that improves the quality of sleep and life, of patients with cancer. While sleep disturbances are common throughout breast cancer treatment, such symptoms remain underdiagnosed in clinical practice. Frequency, severity, and pattern of insomnia vary during treatment, affecting patients after the first cycle of chemotherapy and during the perioperative period. Tryptophan low levels, an essential amino acid for protein synthesis and precursor of the neurotransmitter serotonin and melatonin metabolite, may be related to these symptoms. The aim was reviewing the literature on the action of melatonin and tryptophan, supplemented orally, on the sleep quality of women undergoing breast cancer treatment. A search for articles published between January 2010 and December 2021 in Lilacs, PubMed, Science Direct, Scopus, and Web of Science databases, yielded 883 articles. And, based on the inclusion criteria, 6 studies were selected in this integrative review. The results show the benefit and efficiency of using melatonin supplementation on the quality and total sleep time, associated with the perioperative of breast cancer and during its treatment. It was possible to identify that tryptophan supplementation led to an increase in circulating melatonin and decrease the prevalence of insomnia that affects the study population.
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