Exploring the antioxidant properties of rosmarinus officinalis essential oil and its traditional applications: scope review

Autores

Palavras-chave:

Antioxidants, ethnopharmacology, Plants, Rosmarinus officinalis L, Therapeutics

Resumo

The ethnopharmacology of rosemary and the historical recognition of its medicinal properties have proven to be crucial for scientifically validating its traditional use and exploring its therapeutic potential in public health for various diseases. In the current context of seeking new natural and alternative therapies, it is crucial to explore the medicinal properties of plants like rosemary, which has been used for centuries for therapeutic purposes. This study aimed to conduct an analysis of the antioxidant activity of Rosmarinus officinalis essential oil. To achieve this goal, we followed the protocol established by the Joanna Briggs Institute Reviewer's Manual, ensuring the methodological quality of the research and protocol transparency by registering the study on the Open Science Framework (OSF). The research findings revealed 31 studies with antioxidant activity in essential oils, highlighting Morocco and Tunisia as regions with the most studies on rosemary and antioxidant activity, with the compounds 1,8-cineole and alpha-pinene being the main responsible for this activity. These findings not only corroborate the ethnofarmacological tradition associated with rosemary but also provide valuable information for future investigations into its therapeutic potential. The need to explore the medicinal properties of rosemary in a contemporary context is emphasized by the growing demand for natural and alternative therapies, as well as the importance of scientifically validating traditional knowledge about the use of medicinal plants. Furthermore, gaining a better understanding of the therapeutic properties of rosemary and its active compounds can significantly contribute to public health in the pursuit of new therapies.

Keywords: Antioxidants; ethnopharmacology; Plants; Rosmarinus officinalis L; Therapeutics.

 

Resumo

A etnofarmacologia do alecrim e o reconhecimento histórico de suas propriedades medicinais são fundamentais para validar cientificamente sua utilização tradicional e explorar seu potencial terapêutico na saúde pública para diversas doenças. Em um contexto de busca por novas terapias naturais e alternativas, é crucial explorar as propriedades medicinais de plantas como o alecrim, utilizado há séculos com propósitos terapêuticos. Este estudo teve como objetivo analisar a atividade antioxidante do óleo essencial de Rosmarinus officinalis. Para alcançá-lo, seguimos o protocolo estabelecido pelo Manual do Revisor do Instituto Joanna Briggs, garantindo a qualidade metodológica da pesquisa e o registro no Open Science Framework (OSF). Os resultados revelaram 31 estudos com atividade antioxidante em óleos essenciais, destacando Marrocos e Tunísia como regiões com maior estudo do alecrim e atividade antioxidante, sendo o 1,8-cineol e o alfa-pineno os principais responsáveis por essa atividade. Esses achados corroboram a tradição etnofarmacológica associada ao alecrim e fornecem informações valiosas para futuras investigações sobre seu potencial terapêutico. A necessidade de explorar as propriedades medicinais do alecrim em um contexto contemporâneo é enfatizada pela crescente demanda por terapias naturais e alternativas, bem como pela importância de validar cientificamente o conhecimento tradicional sobre o uso de plantas medicinais. Além disso, compreender melhor as propriedades terapêuticas do alecrim e de seus compostos ativos pode contribuir significativamente para a saúde pública na busca por novas terapias.

Palavras-chave: Antioxidantes; etnofarmacologia; Plantas; Rosmarinus officinalis L; Terapêutica.

Referências

ABU-AL-BASAL, M. A. Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. Journal of Ethnopharmacology, v. 131, n. 2, p. 443-450, 15 set. 2010.

AL-MAHARIK, N. et al. Chemical Composition, Antioxidant, Antimicrobial and Anti-Proliferative Activities of Essential Oils of Rosmarinus officinalis from five Different Sites in Palestine. Separations, v. 9, n. 11, p. 339, nov. 2022.

AL-MEGRIN, W. A. et al. Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2. Bioscience Reports, v. 40, n. 6, p. BSR20200992, 10 jun. 2020.

ALVARADO-GARCÍA, P. et al. Effect of Rosmarinus Officinalis Essential Oil On Anxiety, Depression, And Sleep Quality. Pharmacognosy Journal, v. 15, n. 2, p. 343-349, 2023.

ALVI, S. S. et al. Secondary Metabolites from Rosemary (Rosmarinus officinalis L.): Structure, Biochemistry and Therapeutic Implications Against Neurodegenerative Diseases. Em: SWAMY, M. K.; AKHTAR, M. S. (Eds.). Natural Bio-active Compounds: Volume 2: Chemistry, Pharmacology and Health Care Practices. Singapore: Springer, 2019. p. 1-24.

AMINA, B. et al. Chemical profiling, antioxidant, enzyme inhibitory and in silico modeling of Rosmarinus officinalis L. and Artemisia herba alba Asso. essential oils from Algeria. South African Journal of Botany, v. 147, p. 501-510, 1 jul. 2022.

ANDRADE, J. M. et al. Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity. Future Science OA, v. 4, n. 4, p. FSO283, abr. 2018.

AOUADI, M. et al. Essential oil of Rosmarinus officinalis induces in vitro anthelmintic and anticoccidial effects against Haemonchus contortus and Eimeria spp. in small ruminants. Veterinární medicína, v. 66, n. 4, p. 146-155, 30 abr. 2021.

AQEL, M. B. Relaxant effect of the volatile oil of Romarinus officinalis on tracheal smooth muscle. Journal of Ethnopharmacology, v. 33, n. 1, p. 57-62, 1 maio 1991.

ARFA, A. B. et al. Seasonal changes in rosemary species: A chemotaxonomic assessment of two varieties based on essential oil compounds, antioxidant and antibacterial activities. PLOS ONE, v. 17, n. 8, p. e0273367, 29 ago. 2022.

AROMATARIS, E., et al. Chapter 11: Scoping reviews - JBI Manual for Evidence Synthesis - JBI Global Wiki. Disponível em: https://jbi-global-wiki.refined.site/space/MANUAL/4687342/Chapter+11%3A+Scoping+reviews. Acesso em: 11 dez. 2023.

ATTI-SANTOS, A. C. et al. Physico-chemical evaluation of Rosmarinus officinalis L. essential oils. Brazilian Archives of Biology and Technology, v. 48, p. 1035–1039, nov. 2005.

AZIZ, E. et al. Rosemary species: a review of phytochemicals, bioactivities and industrial applications. South African Journal of Botany, Biotechnological exploration of natural products as functional food and medicine. v. 151, p. 3-18, 1 dez. 2022.

BARBOSA, V. et al. Avaliação da atividade antibacteriana do óleo essencial de Rosmarinus officinalis L. e tintura de própolis frente à bactéria causadora da acne Propionibacterium acnes. Revista Brasileira de Plantas Medicinais, v. 16, p. 169-173, jun. 2014.

BECER, E. et al. Composition and antibacterial, anti-inflammatory, antioxidant, and anticancer activities of Rosmarinus officinalis L. essential oil. South African Journal of Botany, v. 160, p. 437-445, 1 set. 2023.

BEKTAŠEVIĆ, M. et al. Biological Application of Essential Oils and Essential Oils Components in Terms of Antioxidant Activity and Inhibition of Cholinesterase Enzymes. Em: Essential Oils - Advances in Extractions and Biological Applications. [s.l.] IntechOpen, 2022.

BENYOUCEF, F. et al. Synergistic Antioxidant Activity and Chemical Composition of Essential Oils From Thymus fontanesii, Artemisia herba-alba and Rosmarinus officinalis. Journal of Applied Biotechnology Reports, v. 5, n. 4, p. 151–156, 1 dez. 2018.

BERETTA, G. et al. An analytical and theoretical approach for the profiling of the antioxidant activity of essential oils: The case of Rosmarinus officinalis L. Journal of Pharmaceutical and Biomedical Analysis, v. 55, n. 5, p. 1255-1264, 15 jul. 2011.

BOIX, Y. F. et al. Assessment of the Antioxidative Potential of Rosmarinus officinalis L. (Lamiaceae) Irrigated with Static Magnetic Field-Treated Water. Brazilian Archives of Biology and Technology, v. 63, p. e20190142, 10 ago. 2020.

BORGES, R. S. et al. Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved. Journal of Ethnopharmacology, v. 229, p. 29-45, 30 jan. 2019.

BOUAMMALI, H. et al. Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study. Plants, v. 13, n. 1, p. 89, jan. 2024.

BOUYAHYA, A. et al. Chemical composition of Mentha pulegium and Rosmarinus officinalis essential oils and their antileishmanial, antibacterial and antioxidant activities. Microbial Pathogenesis, v. 111, p. 41-49, 1 out. 2017.

BOUZENNA, H. et al. Potential protective effects of alpha-pinene against cytotoxicity caused by aspirin in the IEC-6 cells. Biomedicine & Pharmacotherapy, v. 93, p. 961-968, 1 set. 2017.

BRASIL. Política e Programa Nacional de Plantas Medicinais e Fitoterápicos. Disponível em: https://www.gov.br/saude/pt-br/composicao/sectics/pnpmf/ppnpmf/politica-e-programa-nacional-de-plantas-medicinais-e-fitoterapicos. Acesso em: 13 maio. 2024.

CAI, Z.-M. et al. 1,8-Cineole: a review of source, biological activities, and application. Journal of Asian Natural Products Research, v. 23, n. 10, p. 938-954, 3 out. 2021.

CASSIDY, L. et al. Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics. Complementary Therapies in Medicine, v. 49, p. 102294, 1 mar. 2020.

CHEMDRAW. Revvity Signals Software. Disponível em: https://revvitysignals.com/products/research/chemdraw. Acesso em: 13 maio 2024.

COBLEY, J. N. et al. Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations. Free Radical Biology and Medicine, v. 84, p. 65-76, 1 jul. 2015.

CONDE-HERNÁNDEZ, L. A. et al. CO2-supercritical extraction, hydrodistillation and steam distillation of essential oil of rosemary (Rosmarinus officinalis). Journal of Food Engineering, v. 200, p. 81-86, 1 maio 2017.

CUEVAS-DURÁN, R. E. et al. Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents. International Journal of Molecular Sciences, v. 18, n. 11, p. 2412, nov. 2017.

DE MACEDO, L. M. et al. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review. Plants, v. 9, n. 5, p. 651, maio 2020.

DE MENEZES, B. B. et al. A critical examination of the DPPH method: Mistakes and inconsistencies in stoichiometry and IC50 determination by UV–Vis spectroscopy. Analytica Chimica Acta, v. 1157, p. 338398, 1 maio 2021.

DEFEUDIS, F. V.; PAPADOPOULOS, V.; DRIEU, K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundamental & Clinical Pharmacology, v. 17, n. 4, p. 405-417, ago. 2003.

DEGNER, S. C.; PAPOUTSIS, A. J.; ROMAGNOLO, D. F. Chapter 26 - Health Benefits of Traditional Culinary and Medicinal Mediterranean Plants. In: WATSON, R. R. (Ed.). Complementary and Alternative Therapies and the Aging Population. San Diego: Academic Press, 2009. p. 541-562.

DI, Y. et al. Effects of Dietary 1,8-Cineole Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestine Health of Broilers. Animals, v. 12, n. 18, p. 2415, jan. 2022.

DUBOIS-DERUY, E. et al. Oxidative Stress in Cardiovascular Diseases. Antioxidants, v. 9, n. 9, p. 864, set. 2020.

EL KHARRAF, S. et al. Hydrodistillation and simultaneous hydrodistillation-steam distillation of Rosmarinus officinalis and Origanum compactum: Antioxidant, anti-inflammatory, and antibacterial effect of the essential oils. Industrial Crops and Products, v. 168, p. 113591, 15 set. 2021.

EL-DEMERDASH, F. M.; EL-SAYED, R. A.; ABDEL-DAIM, M. M. Rosmarinus officinalis essential oil modulates renal toxicity and oxidative stress induced by potassium dichromate in rats. Journal of Trace Elements in Medicine and Biology, v. 67, p. 126791, 1 set. 2021.

FÁSI, L. et al. AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite. Biomolecules, v. 10, n. 11, p. 1537, nov. 2020.

FELICIDADE, I. et al. Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa. Genetics and molecular research: GMR, v. 13, n. 4, p. 9986-9996, 28 nov. 2014.

FIRENZUOLI, F. et al. Essential Oils: New Perspectives in Human Health and Wellness. Evidence-Based Complementary and Alternative Medicine, v. 2014, p. e467363, 22 jun. 2014.

FLIEGER, J.; FLIEGER, M. The [DPPH●/DPPH-H]-HPLC-DAD Method on Tracking the Antioxidant Activity of Pure Antioxidants and Goutweed (Aegopodium podagraria L.) Hydroalcoholic Extracts. Molecules, v. 25, n. 24, p. 6005, jan. 2020.

GAD, A. S.; SAYD, A. F. Antioxidant Properties of Rosemary and Its Potential Uses as Natural Antioxidant in Dairy Products—A Review. Food and Nutrition Sciences, v. 6, n. 1, p. 179-193, 12 jan. 2015.

GARZOLI, S. et al. Headspace/GC–MS Analysis and Investigation of Antibacterial, Antioxidant and Cytotoxic Activity of Essential Oils and Hydrolates from Rosmarinus officinalis L. and Lavandula angustifolia Miller. Foods, v. 10, n. 8, p. 1768, ago. 2021.

GAYA, M. et al. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. Biochimica et Biophysica Acta (BBA) - General Subjects, v. 1830, n. 6, p. 3796-3806, 1 jun. 2013.

GHASEMZADEH RAHBARDAR, M.; HOSSEINZADEH, H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iranian Journal of Basic Medical Sciences, v. 23, n. 9, p. 1100-1112, set. 2020.

GOKBULUT, I.; KARAMAN, Y.; TURSUN, A. Chemical composition phenolic, antioxidant, and bio-herbicidal properties of the essential oil of rosemary (Rosmarinus officinalis L.). Acta Scientiarum Polonorum Hortorum Cultus, v. 21, p. 21-29, 31 ago. 2022.

GONÇALVES, C. et al. Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation. Molecules, v. 27, n. 3, p. 609, jan. 2022.

GONÇALVES, G. A. et al. Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid. Food Chemistry, v. 271, p. 393-400, 15 jan. 2019.

GONÇALVES, G. DE A. et al. Water soluble compounds of Rosmarinus officinalis L. improve the oxidative and inflammatory states of rats with adjuvant-induced arthritis. Food & Function, v. 9, n. 4, p. 2328-2340, 25 abr. 2018.

GONZÁLEZ-MINERO, F. J.; BRAVO-DÍAZ, L.; AYALA-GÓMEZ, A. Rosmarinus officinalis L. (Rosemary): An Ancient Plant with Uses in Personal Healthcare and Cosmetics. Cosmetics, v. 7, n. 4, p. 77, dez. 2020.

HALOUI, M. et al. Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea. Journal of Ethnopharmacology, v. 71, n. 3, p. 465-472, 1 ago. 2000.

HAMZA, B. et al. Wound healing activity of the essential oils of Rosmarinus officinalis and Populus alba in a burn wound model in rats. v. 1, 2020.

HOCH, C. C. et al. 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases. Biomedicine & Pharmacotherapy, v. 167, p. 115467, 1 nov. 2023.

HOSSAIN, M. A.; ASADA, K. Monodehydroascorbate reductase from cucumber is a flavin adenine dinucleotide enzyme. The Journal of Biological Chemistry, v. 260, n. 24, p. 12920-12926, 25 out. 1985.

HUNYADI, A. The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites. Medicinal Research Reviews, v. 39, n. 6, p. 2505-2533, 2019.

HUSSAIN, A. I. et al. Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities. Brazilian Journal of Microbiology, v. 41, p. 1070-1078, dez. 2010.

JIANG, T. A. Health Benefits of Culinary Herbs and Spices. Journal of AOAC INTERNATIONAL, v. 102, n. 2, p. 395-411, 1 mar. 2019.

JUERGENS, L. J. et al. Regulation of monocyte redox balance by 1,8-cineole (eucalyptol) controls oxidative stress and pro-inflammatory responses in vitro: A new option to increase the antioxidant effects of combined respiratory therapy with budesonide and formoterol? Synergy, v. 7, p. 1-9, 1 dez. 2018.

KACHMAR, M. R. et al. Traditional Knowledge of Medicinal Plants Used in the Northeastern Part of Morocco. Evidence-Based Complementary and Alternative Medicine, v. 2021, p. e6002949, 6 ago. 2021.

KAKDE, K.; K, R. Tooth Autotransplantation as an Alternative Biological Treatment: A Literature Review. Cureus, v. 14, n. 10, p. e30491, out. 2022.

KARATAŞ, T. et al. Effects of Rosemary (Rosmarinus officinalis) extract on growth, blood biochemistry, immunity, antioxidant, digestive enzymes and liver histopathology of rainbow trout, Oncorhynchus mykiss. Aquaculture Nutrition, v. 26, n. 5, p. 1533-1541, 2020.

KHADIM, R. M.; AL-FARTUSIE, F. S. Antioxidant vitamins and their effect on immune system. Journal of Physics: Conference Series, v. 1853, n. 1, p. 012065, 1 mar. 2021.

LABIAD, H. et al. Ethnopharmacological survey of aromatic and medicinal plants of the pharmacopoeia of northern Morocco. Ethnobotany Research and Applications, v. 19, p. 1-16, 12 maio 2020.

LADAN MOGHADAM, A. R. Antioxidant Activity and Chemical Composition of Rosmarinus officinalis L. Essential Oil from Iran. Journal of Essential Oil Bearing Plants, v. 18, n. 6, p. 1490-1494, 2 nov. 2015.

LEV, E. Ethno-diversity within current ethno-pharmacology as part of Israeli traditional medicine – A review. Journal of Ethnobiology and Ethnomedicine, v. 2, n. 1, p. 4, 9 jan. 2006.

LI POMI, F. et al. Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases. Antioxidants, v. 12, n. 3, p. 680, 9 mar. 2023.

LI, T. et al. Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia. Journal of Ethnopharmacology, v. 318, p. 116984, 10 jan. 2024.

LI, X.-W. et al. Rosmarinus officinialis L. (Lamiales: Lamiaceae), a Promising Repellent Plant for Thrips Management. Journal of Economic Entomology, v. 114, n. 1, p. 131-141, 1 fev. 2021.

LIN, P.-C.; LEE, J. J.; CHANG, I.-J. Essential oils from Taiwan: Chemical composition and antibacterial activity against Escherichia coli. Journal of Food and Drug Analysis, v. 24, n. 3, p. 464-470, 1 jul. 2016.

LINDHEIMER, J. B.; LOY, B. D.; O’CONNOR, P. J. Short-Term Effects of Black Pepper (Piper nigrum) and Rosemary (Rosmarinus officinalis and Rosmarinus eriocalyx) on Sustained Attention and on Energy and Fatigue Mood States in Young Adults with Low Energy. Journal of Medicinal Food, v. 16, n. 8, p. 765-771, ago. 2013.

LOZANO-GRANDE, M. A. et al. Plant Sources, Extraction Methods, and Uses of Squalene. International Journal of Agronomy, v. 2018, p. e1829160, 1 ago. 2018.

LÜ, J.-M. et al. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. Journal of Cellular and Molecular Medicine, v. 14, n. 4, p. 840-860, abr. 2010.

LUCARINI, R. et al. In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative. Pharmaceutical Biology, v. 51, n. 9, p. 1087-1090, 1 set. 2013.

MARTINEZ-MORALES, F. et al. Use of standardized units for a correct interpretation of IC50 values obtained from the inhibition of the DPPH radical by natural antioxidants. Chemical Papers, v. 74, n. 10, p. 3325-3334, 1 out. 2020.

MASYITA, A. et al. Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives. Food Chemistry: X, v. 13, p. 100217, 30 mar. 2022.

MEKONNEN, A. et al. In Vitro Antimicrobial Activity of Essential Oil of Thymus schimperi, Matricaria chamomilla, Eucalyptus globulus, and Rosmarinus officinalis. International Journal of Microbiology, v. 2016, p. 9545693, 2016.

MEZIANE, H. et al. Rosmarinus officinalis Linn.: unveiling its multifaceted nature in nutrition, diverse applications, and advanced extraction methods. Journal of Umm Al-Qura University for Applied Sciences, 3 abr. 2024.

MICHALAK, M. Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. International Journal of Molecular Sciences, v. 23, n. 2, p. 585, jan. 2022.

MIGUEL, M. G. Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review. Molecules, v. 15, n. 12, p. 9252-9287, dez. 2010.

MORETTI, M. D. L. et al. Effects of Soil Properties on Yield and Composition of Rosmarinus officinalis Essential Oil. Journal of Essential Oil Research, v. 10, n. 3, p. 261-267, 1 maio 1998.

MOUFAKKIR, C. et al. Antioxidant effect of natural rosemary on the oxidation of mid-oleic sunflower frying oil on chicken wings. Food Science and Technology, v. 42, p. e70122, 14 out. 2022.

NAM, S.-Y. et al. The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis. International Immunopharmacology, v. 23, n. 1, p. 273-282, nov. 2014.

NIMSE, S. B.; PAL, D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Advances, v. 5, n. 35, p. 27986–28006, 16 mar. 2015.

NOBILE, V. et al. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols. Food & Nutrition Research, v. 60, 1 jul. 2016.

NORDIN, M. L. et al. In vitro investigation of cytotoxic and antioxidative activities of Ardisia crispa against breast cancer cell lines, MCF-7 and MDA-MB-231. BMC Complementary and Alternative Medicine, v. 18, n. 1, p. 87, 12 mar. 2018.

OJEDA-SANA, A. M. et al. New insights into antibacterial and antioxidant activities of rosemary essential oils and their main components. Food Control, v. 31, n. 1, p. 189-195, 1 maio 2013.

OLIVEIRA, L. G. DE; FARIA, M. L. DE; AMORIM, E. S. Estudo Da Atividade Antioxidante Do Óleo Essencial De Alecrim (Rosmarinus Officinalis L) No Tratamento Ao Estresse Oxidativo Na Doença De Alzheimer: Study of the Antioxidant Activity of Rosemary Essential Oil (Rosmarinus Officinalis L) in the Treatment of Oxidative Stress in Alzheimer’s Disease. STUDIES IN EDUCATION SCIENCES, v. 2, n. 3, p. 238-246, 2021.

OLIVEIRA, G. L. S. Determinação da capacidade antioxidante de produtos naturais in vitro pelo método do DPPH•: estudo de revisão. Revista Brasileira de Plantas Medicinais, v. 17, p. 36-44, mar. 2015.

OLIVEIRA, J. C. A.; VEIGA, R. DA S. Impacto do uso do alecrim - Rosmarinus officinalis L. - para a saúde humana. Brazilian Journal of Natural Sciences, v. 2, n. 1, p. 12-12, 11 jan. 2019.

OUALDI, I. et al. Rosmarinus officinalis from Morocco, Italy and France: Insight into chemical compositions and biological properties. Materials Today: Proceedings, The Fourth edition of the International Conference on Materials & Environmental Science. v. 45, p. 7706-7710, 1 jan. 2021.

OUKNIN, M. et al. Enzyme inhibitory, antioxidant activity and phytochemical analysis of essential oil from cultivated Rosmarinus officinalis. Journal of Food Measurement and Characterization, v. 15, n. 4, p. 3782-3790, 1 ago. 2021.

OZAROWSKI, M. et al. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia, v. 91, p. 261-271, 1 dez. 2013.

PEIRETTI, P. G. et al. Effects of Rosemary Oil (Rosmarinus officinalis) on the Shelf-Life of Minced Rainbow Trout (Oncorhynchus mykiss) during Refrigerated Storage. Foods, v. 1, n. 1, p. 28-39, dez. 2012.

PHAM-HUY, L. A.; HE, H.; PHAM-HUY, C. Free Radicals, Antioxidants in Disease and Health. International Journal of Biomedical Science : IJBS, v. 4, n. 2, p. 89, jun. 2008.

PINTORE, G. et al. Rosmarinus officinalis L.: Chemical Modifications of the Essential oil and Evaluation of Antioxidant and Antimicrobial Activity. Natural Product Communications, v. 4, n. 12, p. 1934578X0900401215, 1 dez. 2009.

PIRINTSOS, S. et al. From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples. Molecules, v. 27, n. 13, p. 4060, 2022.

POPRAC, P. et al. Targeting Free Radicals in Oxidative Stress-Related Human Diseases. Trends in Pharmacological Sciences, v. 38, n. 7, p. 592–607, 1 jul. 2017.

PRAKASH, B. et al. Assessment of chemically characterised Rosmarinus officinalis L. essential oil and its major compounds as plant-based preservative in food system based on their efficacy against food-borne moulds and aflatoxin secretion and as antioxidant. International Journal of Food Science & Technology, v. 50, n. 8, p. 1792-1798, 2015.

PRETTO, C. R. et al. Tendência das produções científicas brasileiras acerca do potencial terapêutico do Alecrim à saúde. Research, Society and Development, v. 10, n. 9, p. e50910918255–e50910918255, 1 ago. 2021.

RAFIE HAMIDPOUR1*; SOHEILA HAMIDPOUR2; GRANT ELIAS1. Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti- Inflammatory, and Anti-Obesity Treatment. Biomedical Journal of Scientific and Technical Research, v. 1, n. 4, p. 001–006, 20 set. 2017.

RAŠKOVIĆ, A. et al. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complementary and Alternative Medicine, v. 14, n. 1, p. 225, 7 jul. 2014.

RIBEIRO-SANTOS, R. et al. A novel insight on an ancient aromatic plant: The rosemary (Rosmarinus officinalis L.). Trends in Food Science & Technology, v. 45, n. 2, p. 355-368, 1 out. 2015.

RISALITI, L. et al. Liposomes loaded with Salvia triloba and Rosmarinus officinalis essential oils: In vitro assessment of antioxidant, antiinflammatory and antibacterial activities. Journal of Drug Delivery Science and Technology, v. 51, p. 493-498, 1 jun. 2019.

ROCHA, J. et al. Anti-inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation. Basic & Clinical Pharmacology & Toxicology, v. 116, n. 5, p. 398-413, 2015.

ROOHBAKHSH, Y. et al. Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion. Planta Medica, v. 86, n. 06, p. 405-414, abr. 2020.

ROSA, J. S. DA et al. Systemic Administration of Rosmarinus officinalis Attenuates the Inflammatory Response Induced by Carrageenan in the Mouse Model of Pleurisy. Planta Medica, v. 79, n. 17, p. 1605-1614, nov. 2013.

ROSMARINUS OFFICINALIS L. Word flora Disponível em: https://www.worldfloraonline.org/taxon/wfo-0000298062. Acesso em: 14 mar. 2024.

RUBIÓ, L.; MOTILVA, M.-J.; ROMERO, M.-P. Recent Advances in Biologically Active Compounds in Herbs and Spices: A Review of the Most Effective Antioxidant and Anti-Inflammatory Active Principles. Critical Reviews in Food Science and Nutrition, v. 53, n. 9, p. 943-953, 1 jan. 2013.

RUSSO, E. B.; MARCU, J. Chapter Three - Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Em: KENDALL, D.; ALEXANDER, S. P. H. (Eds.). Advances in Pharmacology. Cannabinoid Pharmacology. [s.l.] Academic Press, 2017. v. 80p. 67-134.

RUTUJA P. KHAIRNAR*, S. B. D., Rutuja N. Pinjarkar ,. Rutuja B. Aher. Rosmarinus Officinalis L. : Used For the Treatment of Hair Loss. International Journal in Pharmaceutical Sciences, v. 1, n. 12, p. 537-546, 19 dez. 2023.

SABBAHI, M. et al. Volatile Variability and Antioxidant Activity of Rosmarinus officinalis Essential Oil as Affected by Elevation Gradient and Vegetal Associations. Asian Journal of Chemistry, v. 31, n. 6, p. 1279-1288, 29 abr. 2019.

SAKAR, E. H. et al. Combined Effects of Domestication and Extraction Technique on Essential Oil Yield, Chemical Profiling, and Antioxidant and Antimicrobial Activities of Rosemary (Rosmarinus officinalis L.). Journal of Food Biochemistry, v. 2023, p. e6308773, 8 mar. 2023.

SÁNCHEZ-MARZO, N. et al. Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model. Antioxidants, v. 9, n. 3, p. 255, mar. 2020.

SÁNCHEZ-QUINTERO, M. J. et al. Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus. Nutrients, v. 14, n. 21, p. 4650, jan. 2022.

SELMI, S. et al. Rosemary (Rosmarinus officinalis) essential oil components exhibit anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects in experimental diabetes. Pathophysiology, v. 24, n. 4, p. 297-303, 1 dez. 2017.

SHARMA, A. D.; KAUR, I.; CHAUHAN, A. Molecular docking studies of principal components and in vitro inhibitory activities of Rosmarinus officinalis essential oil against Aspergillus flavus, Aspergillus fumigatus and Mucor indicus. Phytomedicine Plus, v. 3, n. 4, p. 100493, 1 nov. 2023.

SHARMA, O. P.; BHAT, T. K. DPPH antioxidant assay revisited. Food Chemistry, v. 113, n. 4, p. 1202-1205, 15 abr. 2009.

SIES, H. Oxidative Stress: Concept and Some Practical Aspects. Antioxidants, v. 9, n. 9, p. 852, set. 2020.

STORZ, G.; IMLAYT, J. A. Oxidative stress. Current Opinion in Microbiology, v. 2, n. 2, p. 188-194, 1 abr. 1999.

TAHOONIAN-GOLKHATMY, F. et al. Comparison of Rosemary and Mefenamic Acid Capsules on Menstrual Bleeding and Primary Dysmenorrhea: A Clinical Trial. Iranian Journal of Nursing and Midwifery Research, v. 24, n. 4, p. 301-305, 2019.

TRICCO, A. C. et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, v. 169, n. 7, p. 467-473, 2 out. 2018.

VALONES, M. A. A. et al. Clinical Assessment of Rosemary-based Toothpaste (Rosmarinus officinalis Linn.): A Randomized Controlled Double-blind Study. Brazilian Dental Journal, v. 30, p. 146-151, 4 abr. 2019.

WANG, B. et al. Report: Regional variation in the chemical composition and antioxidant activity of Rosmarinus officinalis L. from China and the Mediterranean region. Pakistan Journal of Pharmaceutical Sciences, v. 31, n. 1, p. 221-229, jan. 2018.

WANG, W. et al. Antioxidative activity of Rosmarinus officinalis L. essential oil compared to its main components. Food Chemistry, v. 108, n. 3, p. 1019-1022, 1 jun. 2008.

WEI, K. et al. Antispasmodic activity of carnosic acid extracted from rosmarinus officinalis: Isolation, spectroscopic characterization, DFT studies, and in silico molecular docking investigations. Journal of Molecular Structure, v. 1260, p. 132795, 15 jul. 2022.

WEI, T.; LIU, Y.; LI, M. Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis. Indian Journal of Pharmaceutical Education and Research, v. 55, n. 2, p. 507-516, 17 maio 2021.

WILSON, L. A. SPICES AND FLAVORING (FLAVOURING) CROPS | Use of Spices in the Food Industry. Em: CABALLERO, B. (Ed.). Encyclopedia of Food Sciences and Nutrition (Second Edition). Oxford: Academic Press, 2003. p. 5460-5465.

YAROSH, A. M. et al. [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension]. Voprosy Kurortologii, Fizioterapii, I Lechebnoi Fizicheskoi Kultury, v. 100, n. 2, p. 22-30, 2023.

YOUSEF, M. et al. Attenuation of allergen-mediated mast cell activation by rosemary extract (Rosmarinus officinalis L.). Journal of Leukocyte Biology, v. 107, n. 5, p. 843-857, 2020.

YUAN, H. et al. The Traditional Medicine and Modern Medicine from Natural Products. Molecules, v. 21, n. 5, p. 559, maio 2016.

YUAN, R. et al. Review of aromatherapy essential oils and their mechanism of action against migraines. Journal of Ethnopharmacology, v. 265, p. 113326, 30 jan. 2021.

ZAOUALI, Y.; BOUZAINE, T.; BOUSSAID, M. Essential oils composition in two Rosmarinus officinalis L. varieties and incidence for antimicrobial and antioxidant activities. Food and Chemical Toxicology, v. 48, n. 11, p. 3144-3152, 1 nov. 2010.

ZRIRA, S. Some Important Aromatic and Medicinal Plants of Morocco. Em: NEFFATI, M.; NAJJAA, H.; MÁTHÉ, Á. (Eds.). Medicinal and Aromatic Plants of the World - Africa Volume 3. Dordrecht: Springer Netherlands, 2017a. p. 91-125.

ZRIRA, S. Some Important Aromatic and Medicinal Plants of Morocco. Em: NEFFATI, M.; NAJJAA, H.; MÁTHÉ, Á. (Eds.). Medicinal and Aromatic Plants of the World - Africa Volume 3. Dordrecht: Springer Netherlands, 2017b. p. 91-125.

Downloads

Publicado

19-12-2024

Como Citar

Fernandes, I. da C., Santos , B. W. do, Miguel , I. D., Anjos, C. A. dos, Dalarmi , L., Montrucchio , D. P., … Miguel , O. G. (2024). Exploring the antioxidant properties of rosmarinus officinalis essential oil and its traditional applications: scope review. REVISTA CIENTÍFICA DA FAMINAS, 19(1), 112–128. Recuperado de https://periodicos.faminas.edu.br/index.php/RCFaminas/article/view/877